Insulin Receptor-Associated Roles of Serotonin Transporter
نویسندگان
چکیده
منابع مشابه
Unifying Concept of Serotonin Transporter-associated Currents*
Serotonin (5-HT) uptake by the human serotonin transporter (hSERT) is driven by ion gradients. The stoichiometry of transported 5-HT and ions is predicted to result in electroneutral charge movement. However, hSERT mediates a current when challenged with 5-HT. This discrepancy can be accounted for by an uncoupled ion flux. Here, we investigated the mechanistic basis of the uncoupled currents an...
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Heightened expression of the S100 calcium-binding protein, S100A4/Mts1, is observed in pulmonary vascular disease. Loss of serotonin (5-hydroxytryptamine [5-HT]) receptors or of the serotonin transporter (SERT) attenuates pulmonary hypertension in animals, and polymorphisms causing gain of SERT function are linked to clinical pulmonary vascular disease. Because 5-HT induces release of S100beta,...
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ژورنال
عنوان ژورنال: American Journal of Biomedical Science & Research
سال: 2021
ISSN: 2642-1747
DOI: 10.34297/ajbsr.2021.12.001714